Symptoms of Buruli ulcer begin with painless nodules and swelling, usually on the arms and legs and sometimes on other parts of the body. These areas can then develop into large ulcers with a white and yellow base. M. ulcerans produces the toxin mycolactone. This has local immunosuppressive properties that enable the disease to progress rapidly with no pain and fever, making early detection difficult. However, if the ulcers are treated quickly, most will heal completely.
If diagnosed late or left untreated, the condition can lead to scarring, permanent disfigurement and disability.
Buruli ulcer has been reported in 33 countries in Africa, the Americas, Asia and the Western Pacific. Most cases occur in tropical and subtropical regions except in Australia, China and Japan. Out of the 33 countries, 14 regularly report data to WHO. The annual number of suspected Buruli ulcer cases reported globally was around 5000 cases until 2010, when it started to decrease until 2016, reaching its minimum of 1961 cases reported. Since then, then number of cases has started to rise again every year up to 2713 cases in 2018. The reasons for the decline and for the recent increase are not clear
Buruli ulcer
Buruli ulcer is a chronic debilitating disease that mainly affects the skin and sometimes bones. First described by Sir Albert Cook in 1897 in Uganda, it was not until the 1930s that Australian scientists led by Peter MacCallum first succeeded in culturing the organism from lesions of patients from the Bairnsdale region. The name Buruli comes from an area of Uganda where many cases were reported in the 1960s. In Africa, about half of the patients are children under 15 years. In Australia, the average age is around 60 years. In 1998, WHO established the Global Buruli Ulcer Initiative in response to the growing spread of the disease, particularly in West Africa.
Buruli ulcer is caused by Mycobacterium and belongs to the family of bacteria that causes tuberculosis and leprosy. Although the causative organism of Buruli ulcer is an environmental bacterium, the mode of transmission to humans remains unknown. The organism produces a unique toxin – mycolactone – that causes the damage to the skin. Early diagnosis and treatment are crucial to minimizing morbidity, costs and prevent long-term disability.
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